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Life Science Frontier · NatureA 1-Gram Wireless Microscope Records 8,500 Brain Cells at Once in Freely Moving MiceResearchers at Tsinghua University developed Airscope, a wireless miniature microscope weighing 1.0 g with a 6 mm field of view. It recorded cortical activity at the level of thousands of cells in mice running and swimming without cables.

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FeatureFiber Drunk as a Beverage Lowered Post-Meal Blood Glucose More: Meta-Analysis of 37 Trials

Drinking 6 g of resistant maltodextrin in a beverage reduced the post-meal blood glucose response by about 20%. A liquid product built on this evidence is now available.

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Metabolism & Aging

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Diabetologia20-Year Follow-Up of 7,186 Koreans: Meeting 3 Prediabetes Criteria Raises Diabetes Risk 15-FoldCell MetabolismFat Tissue Protects Muscle: A Protein Secreted by NAD+ Signaling Suppresses Muscle WastingNature AgingLonger Lipid Chains Identified as a Shared Aging Marker in Worms, Flies, Mice and HumansNature MetabolismEven With Identical Nutrients, Ultraprocessed Food Raised Insulin More: A 57-Person Crossover Trial

Natural Products & Plant Materials

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Journal of Natural ProductsEnzyme AsLOX2 Identified as First Step in Making Saclipin, a UV-Absorbing Compound From an Edible CyanobacteriumAngewandte Chemie International Edition8 New Geranylated Chalcones Isolated From Medicinal Plant Breadfruit; One Protects in a Brain Ischemia ModelJournal of the American Chemical SocietyNew Macrolide 'Canalesolide A' From Marine Cyanobacterium Kills Sleeping Sickness Parasites Within 1 HourNature CommunicationsComplete Biosynthesis of Horse Chestnut Seed Saponin 'Escin Ia' Mapped, With 10 Previously Unknown Enzymes Found

Clinical Research & New Drugs

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Nature MedicineGlyco-Engineered Anti-CD20 Antibody Cuts Relapse Risk 93% in Neuromyelitis Optica Phase 3 TrialJAMAPD-1/VEGF Bispecific Antibody Ivonescimab Extends Survival by 2.7 Months in EGFR Lung Cancer Phase 3 TrialBMJEarly BCG and Polio Vaccination of Low-Birth-Weight Newborns Lowers Death Risk by 17%The New England Journal of MedicineCardiac Myosin Inhibitor Aficamten Beats Beta-Blocker Metoprolol in Head-to-Head Phase 3 Trial

Brain Science & Mental Health

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JAMA Psychiatry6 Weeks of Ketogenic Diet for Treatment-Resistant Depression Lowers Depression Scores Slightly More Than a Control DietNature Medicine5,000 to 7,500 Steps a Day Slow Tau Buildup and Cognitive Decline in Older Adults With AmyloidJAMATwo Years of a Structured Lifestyle Program Raise Older Adults' Cognitive Scores More Than a Self-Guided OneNatureColon Cells Detect Bacterial Flagellin and Send the Brain a 'Stop Eating' Signal: Mouse Study

Food, Nutrition & Regulation

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Food ChemistryFermenting Chickpea Flour With 4 Lactic Acid Bacteria Reduced Allergenicity and Raised Antioxidant CapacityFood and Chemical ToxicologyCyanotoxin Contamination in Spirulina and Chlorella Supplements: A Roundup of Liver and Nerve Toxicity MechanismsThe American Journal of Clinical NutritionTop 25% for Mediterranean Lifestyle Had 30% Lower Risk of Death: 100,000 People Followed for 13 YearsFamily Medicine and Community HealthEach 100 g More Ultraprocessed Food a Day Raises Cardiovascular Risk 14%: 51 Cohorts, 8.82 Million People

Life Science Frontier

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NatureA 1-Gram Wireless Microscope Records 8,500 Brain Cells at Once in Freely Moving MiceThe LancetAntibody Cuts New Lesions From 19 to 1 in FOP, a Rare Disease That Turns Muscle Into Bone: Phase 3CellMap of 1.6 Million Structural Variants From 467,000 Genomes Yields 28,000 Health AssociationsThe New England Journal of MedicineOne-Time CRISPR Editing Injection Cuts Hereditary Angioedema Attacks by 87%: Phase 3

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